ALDH2 Deficiency is genetically inherited and is present in 35-40% of people of East Asian descent. ALDH2 Deficiency is primarily found in individuals of Chinese, Japanese, and Korean descent. To find out if you have the mutated ALDH2 Gene, you can have your entire genome tested with a simple kit. It only takes one of those ALDH2 Genes to be mutated for an individual to have ALDH2 Deficiency. Please enable it to take advantage of the complete set of features! The oxidation of acetaldehyde to acetate can be summarized as follows: Individuals with ALDH2 Deficiency either have 1 or 2 mutated ALDH2 Genes. SDF-1α as a therapeutic stem cell homing factor in myocardial infarction. The father has ALDH2 Deficiency with 2 mutated genes. ALDH2 is a mitochondrial enzyme found in the liver and mucosa of the upper intestinal tract, among other tissues, and is primarily responsible for the oxidation of simple aldehydes such as acetaldehyde, a potential carcinogen. 2015 Feb;1852(2):310-8. doi: 10.1016/j.bbadis.2014.07.014. Epub 2013 Jan 12. Ghadge SK, Mühlstedt S, Ozcelik C, Bader M. Pharmacol Ther.  |  However, the expression patterns and specific functions of ALDH2 in skeletal muscles are still unclear. HHS You can spread awareness about ALDH2 Deficiency by sharing information with friends, family, and your community. Theranostics. Cardiac fibrosis is a common feature of various cardiovascular diseases. This site needs JavaScript to work properly. There is no exact data point for how many people have ALDH2 Deficiency, but estimates range between 35-50% of all individuals of East Asian descent and from 600 million to over 1 billion globally. Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway. Acetaldehyde is a carcinogen that gets into the body in a number of different ways. This study aimed to investigate the effect of ALDH2 deficiency on cardiac fibrosis in transverse aortic … Being deficient in the ALDH2 enzyme means that your body is less able to safely deal with a particular set of toxins that can enter from the external environment. ALDH2 Deficiency is genetically inherited and is present in 35-40% of people of East Asian descent. The easiest way to tell if you have ALDH2 Deficiency is whether or not you experience Alcohol Flush Reaction. Background: It is estimated that 1 billion people in the world have a point mutation in the gene encoding the aldehyde dehydrogenase 2 (ALDH2) enzyme, the primary enzyme responsible for the metabolism of acetaldehyde. Please feel free to promote this information by sharing this page on Facebook or Twitter. Epub 2020 Oct 19. Nearly 8% of the world's population have an inactivating mutation in the ALDH2 gene. Although Alcohol Flush Reaction is commonly called Asian Flush or Asian Glow, symptoms of ALDH2 Deficiency are also found in Caucasians as well as Native Americans. Alcohol flush reaction (AFR) is a condition in which a person develops flushes or blotches associated with erythema on the face, neck, shoulders, and in some cases, the entire body after consuming alcoholic beverages. The ALDH2 enzyme converts acetaldehyde into non-toxic acetic acid, also known as vinegar. At these concentrations, acetaldehyde causes Alcohol Flush Reaction. That means that around 10% of the entire global population has ALDH2 Deficiency. This is called heterozygous (1 mutated gene) or homozygous (2 mutated genes) for the ALDH2 mutation. Acetaldehyde dehydrogenase 2 (ALDH2) is an enzyme involved in redox homeostasis as well as the detoxification process in alcohol metabolism. Epub 2017 Jun 30. Let’s look at the two scenarios below to understand how this works. 2013;3(1):3-10. doi: 10.7150/thno.4621.  |  NIH Each person has 2 copies of every gene, one from his/her mother, and one from his/her father. Clipboard, Search History, and several other advanced features are temporarily unavailable. Verma SK, Garikipati VNS, Krishnamurthy P, Schumacher SM, Grisanti LA, Cimini M, Cheng Z, Khan M, Yue Y, Benedict C, Truongcao MM, Rabinowitz JE, Goukassian DA, Tilley D, Koch WJ, Kishore R. Circulation. Get the latest public health information from CDC: This enzyme is encoded by the ALDH2 Gene. People of Irish or Scandinavian descent may experience Alcohol Flush Reaction. ALDH2 chimeric mice were generated by bone marrow (BM) transplantation of WT mice into the lethally irradiated ALDH2KO mice. At random, each child will get one of their mother’s genes. In conclusion, our research reveals that increased bone marrow FPCs mobilization and myocardial homing contribute to the enhanced cardiac fibrosis and dysfunction induced by TAC in ALDH2 KO mice via exacerbating accumulation of ROS in BM and myocardial SDF-1 expression. However, the role and mechanisms of cardiac fibrosis in this process remain largely unknown. Epub 2014 Jul 30. Those who are homozygous for the mutation will have an even lower ability to process acetaldehyde, and experience Alcohol Flush Reaction more intensely. ALDH2 stands for Aldehyde Dehydrogenase 2, an important enzyme involved in alcohol metabolism and is responsible for the breakdown of a toxic compound called acetaldehyde. The reaction is the result of an accumulation of acetaldehyde, a metabolic byproduct of the catabolic metabolism of alcohol, and is caused by an aldehyde dehydrogenase 2 deficiency. NLM Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.